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Phospholipase A2 (PLA2)

Phospholipases A2 (PLA2s) are enzymes commonly found in mammalian tissues, which play important role in inflammatory responses. Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins (PGs) and leukotrienes (LTs).