Tyrosine-protein kinase receptor UFO (AXL)

EUPROTEIN has developed and validated the secreted form of the AXL protein expressed in mammalian cell.

Background

Tyrosine-protein kinase receptor UFO (AXL) is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK. This enzyme has been identified as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers.

The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation and survival. Proteolytic cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated downstream of AXL include PI3K-AKT-mTOR, MEKERK, NF-κB, and JAK/STAT.

Implication of AXL in Diseases

AXL is an inhibitor of the innate immune response. The function of activated AXL in normal tissues includes the efficient clearance of apoptotic material and the dampening of TLR-dependent inflammatory responses and natural killer cell activity. Recent studies have identified that the AXL might be one of the entry points other than ACE2, for SARS-CoV-2, the virus that causes COVID-19.

EUPROTEIN Offering

EUPROTEIN has developed and validated these secreted form of the AXL proteins expressed in mammalian cell. These high-quality proteins might be applied in basic research of AXL-related cellular proliferation, as well as studies of COVID-19 mechanisms.

EUPROTEIN also offers SARS-CoV-2 Spike Protein (S1 RBD, Spike NTD & Spike S(S1+S2)) as well as Variants N501Y Spike Protein to help research towards SARS-CoV-2. Please review our list of products here.

Our proteins are 100% manufactured in facility located in New Jersey, US. Expedited shipment can be expected within 24 hours via FEDEX Overnight*.

If you need help expressing the AXL protein or generating antibodies against them, please submit your inquiry.

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Reference

1. Wang, S.; Qiu, Z. et al. (8 Jan 2021). "AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells". Nature https://www.nature.com/articles/s41422-020-00460-y (01/08/2021)
2. Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature https://doi.org/10.1038/s41586-020-2012-7 (2020)
3. Wu, F. et al. A new coronavirus associated with human respiratory disease in China. Nature https://doi.org/10.1038/s41586-020-2008-3 (2020).
4. Letko, Michael; Munster, Vincent (22 January 2020). "Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV". BiorXiv: 2020.01.22.915660. doi:10.1101/2020.01.22.915660.
5. K. Ramkumar et al. 1736P Elevated AXL expression following SARS-CoV-2 infection in non-small cell lung cancer. Ann Oncol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506415/ (Sep. 2020)

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