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Claudin 18.2 Protein (CLDN18.2)

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EUPROTEIN has developed and validated Claudin 18.2 Protein that could be potentially used in the anti-cancer drug discovery.

Human CLDN182. Protein from Expi293 cell
Human CLDN18.2 Protein (EPY202381) from Human Expi293 cells.

Background

Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Implication of CLDN18.2 in Cancer Immunology

Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer.

EUPROTEIN Offering

EUPROTEIN has developed and validated Claudin 18.2 Protein that could be potentially used in the anti-cancer drug discovery.

Human CLDN182. Protein from Expi293 cell
Human CLDN18.2 Protein (EPY202381) from Human Expi293 cells.

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