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TMPRSS2

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UniProt:
GeneID:

EUPROTEIN has developed and validated the secreted form of the TMPRSS2 protein expressed in mammalian cell.

TMPRSS2 protein from Human 293 cells
Human TMPRSS2 protein (EPB223966) from Human 293 cells.

Background

Transmembrane serine protease 2 (TMPS2) that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.


Implication of TMPRSS2 in Diseases

This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus)


EUPROTEIN Offering

EUPROTEIN has developed and validated the secreted form of the TMPRSS2 proteins expressed in mammalian cell. These high-quality proteins might be applied in basic research of TMPRSS2-related cellular proliferation, as well as studies of COVID-19 mechanisms.

TMPRSS2 protein from Human 293 cells
Human TMPRSS2 protein (EPB223966) from Human 293 cells.

EUPROTEIN also offers SARS-CoV-2 Spike Protein (Spike S1 Subunit, S1 RBD & Spike S(S1+S2)) as well as Nucleocapsid Protein to help research towards SARS-CoV-2. Please review our list of products here.

Our proteins are 100% manufactured in facility located in New Jersey, US. Expedited shipment can be expected within 24 hours via FEDEX Overnight*.

If you need help expressing the TMPRSS2 protein or generating antibodies against them, please submit your inquiry.

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* per order approval with validated addresses/payment. Please refer to our temrs for detail requirements.