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Human CYP7B1 protein

SKU
Name
Human CYP7B1 protein
Size
50 ug
Price
$398.00
Qty

Human CYP7B1 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens cytochrome P450 family 7 subfamily B member 1 (CYP7B1), transcript variant 1 (NM_004820), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_004820; NP_004811; UniProt#: O75881; GeneID: 9420;
Synonyms
CBAS3; CP7B; SPG5A
Molecular Weight
58.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016].

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