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Human CYP7A1 protein

SKU
Name
Human CYP7A1 protein
Size
50 ug
Price
$398.00
Qty

Human CYP7A1 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens cytochrome P450 family 7 subfamily A member 1 (CYP7A1) (NM_000780), with a DYKDDDDK tag.
Host
Human Cells
Tags
DYKDDDDK
RefSeq Link
NM_000780; NP_000771; UniProt#: P22680; GeneID: 1581;
Synonyms
CP7A; CYP7; CYPVII
Molecular Weight
57.5 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

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