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Human CYP21A2 protein

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Name
Human CYP21A2 protein
Size
50 ug
Price
$398.00
Qty

Human CYP21A2 protein

Description
Recombinant protein from the full-length sequence of homo sapiens cytochrome P450 family 21 subfamily A member 2 (CYP21A2), transcript variant 1 (NM_000500), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_000500; NP_000491; UniProt#: P08686; GeneID: 1589;
Synonyms
CA21H; CAH1; CPS1; CYP21; CYP21B; P450c21B
Molecular Weight
55.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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