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Recombinant SARS-CoV-2 Spike RBD Protein

SKU
Name
Recombinant SARS-CoV-2 Spike RBD Protein
Size
50 ug
1 mg
Price
$398.00
Qty

Recombinant SARS-CoV-2 Spike RBD Protein

Description
Recombinant protein of the receptor binding domain (RBD) of 2019-nCoV Spike S1 from Wuhan pneumonia virus (MN908947.3) , with a c terminal polyhistidine tag.
Host
Human cells
Tags
His
Source
ECB226512
Synonyms
2019-nCoV;COVID-19;S1 RBD;
Molecular Weight
29.5 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV-2 spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV-2 (2019-nCoV) as in recent COVID-19 outbreak.

SDS-Page Image
Fig 1 : SDS-Page Image
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