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Recombinant SARS-CoV-2 Spike S1 RBD Protein

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Recombinant SARS-CoV-2 Spike S1 RBD Protein
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Recombinant SARS-CoV-2 Spike S1 RBD Protein

Description Recombinant protein of the receptor binding domain (RBD) of SARS-CoV-2 (2019-nCoV) Spike S1 from Wuhan pneumonia virus (MN908947.3) , with a human IgG1 Fc tag.
Host Human cells
Source ECY259461
RefSeq Link NC_045512.2 / MN908947.3; YP_009724390.1 / QHD43416.1; GeneID: 43740568;
Synonyms 2019-nCoV; COVID-19;
Molecular Weight 52.3 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV-2 spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV-2 (2019-nCoV) as in recent COVID-19 outbreak.
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Fig 1 : SDS-Page Image
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