|Description||Recombinant protein from the secreted form (Arg32-Gln220) of Homo sapiens cellular repressor of E1A-stimulated genes 1 (CREG1, NM_003851), with DYKDDDDK and a polyhistidine tag.|
|Host||Human 293 cells|
|Source||Expressed and purified from in vitro cell culture of Human 293 cells with serum-free and animal derived component free conditions|
|RefSeq Link||NM_003851; NP_003842; UniProt#: O75629; GeneID: 8804;|
|Molecular Weight||23.9 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]|
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