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UCHL1

External ID
UniProt:
GeneID:

EUPROTEIN has developed high-quality human UCHL1 proteins that could be used for diagnostic assay development. Only $99 for 25ug!

UCHL1 protein from Human 293 cells
Fig 1. Human UCHL1 protein (EP891883) from Human 293 cells. Datasheet

Background

Ubiquitin carboxy-terminal hydrolase L (UCHL1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary.

Implication of UCHL1 in Diseases

Dysfunction of UCHL1 has been reported in neurodegenerative diseases. An article published in 2014 has shown that UCHL1 may delay Alzheimer's disease progression by regulating amyloid β precursor protein (APP) degradation in a long-term fashion, and that overexpression of UCHL1 may be a safe and effective disease-modifying strategy to treat Alzheimer’s disease.

Similar to Glial fibrillary acidic protein (GFAP), UCHL1 has recently been proposed as a candidate biomarker for brain injury. UCHL1 can be released from injured neurons and flow into the cerebrospinal fluid and circulating blood, and thus is considered a diagnostic candidate for traumatic brain injury (TBI).

EUPROTEIN Offering

EUPROTEIN has developed high-quality human UCHL1 proteins that could be used for diagnostic assay development.

UCHL1 protein from Human 293 cells
Fig 1. Human UCHL1 protein (EP891883) from Human 293 cells.

These proteins are on sale now, only $99 for 25ug! Place order now.

If you would like to express the UCHL1 or GFAP protein or generating antibodies against them, please submit your inquiry

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Reference

  1. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. Doran JF, Jackson P, Kynoch PA, Thompson RJ. Journal of Neurochemistry (1983)
  2. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo. Zhang M, Cai F, Zhang S, Zhang S, Song W. Scientific Reports (2014)
  3. Glial Fibrillary Acidic Protein (GFAP) Outperforms S100 Calcium-Binding Protein B (S100B) and Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) as Predictor for Positive Computed Tomography of the Head in Trauma Subjects. Mahan M, Thorpe M, Ahmadi A, Abdallah T, Casey H, Sturtevant D, Judge-Yoakam S, Hoover C, Rafter D, Miner J, Richardson C, Samadani U. World Neurosurgery (2019)